Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10163615 | 0.92 | GRM4 (0.47) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL13593902 | 0.91 | GRM4 (0.45) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10162798 | 0.91 | GRM4 (0.46) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10162594 | 0.91 | GRM4 (0.48) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10166134 | 0.91 | GRM4 (0.49) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10162599 | 0.90 | MMP13 (0.51) | MMP13WDR5AURKARPS6KB1AURKB | |
| SCHEMBL10162788 | 0.90 | GRM4 (0.51) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10162741 | 0.90 | GRM4 (0.46) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL8231104 | 0.89 | GRM4 (0.50) | GRM4MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL10162825 | 0.89 | MAPT (0.46) | GRM4MAPK1ERBB2EGFRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | GRM4 4373/4885MAPK1 2860/4885HDAC3 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.