Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461910 | 0.67 | ALDH1A1 (0.49) | TRPV1ALDH1A1TDP1MAPTTP53 | |
| SCHEMBL7412813 | 0.67 | TRPV1 (0.45) | TRPV1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7406239 | 0.66 | HPGD (0.45) | TRPV1ALDH1A1TDP1MAPTKDM4E | |
| Ethylene SCHEMBL7414666 | 0.65 | TRPV1 (0.43) | TRPV1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL7407879 | 0.64 | SMN1; SMN2 (0.44) | TRPV1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL14032363 | 0.63 | ALDH1A1 (0.68) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7410546 | 0.62 | TDP1 (0.45) | ALDH1A1TDP1MAPTKMT2AKDM4E | |
| SCHEMBL28288273 | 0.61 | CA1 (0.53) | ALDH1A1MAPTKMT2AMEN1GAA | |
| SCHEMBL25262746 | 0.60 | GAA (0.47) | ALDH1A1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL25258554 | 0.60 | GAA (0.47) | ALDH1A1TDP1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093265-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2012-01-10 | — | — | US | disclosed |