Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019296 | 1.00 | ALDH1A1 (0.57) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL1017425 | 1.00 | ALDH1A1 (0.57) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL1019924 | 0.84 | ALDH1A1 (0.53) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL12765360 | 0.84 | ALDH1A1 (0.53) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL1018424 | 0.84 | ALDH1A1 (0.53) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL15219834 | 0.82 | ALDH1A1 (0.51) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL30927243 | 0.82 | ALDH1A1 (0.51) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL4126470 | 0.81 | FFAR1 (0.70) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL5217474 | 0.81 | FFAR1 (0.70) | ALDH1A1NAMPTLMNAGAAHTT | |
| SCHEMBL2034678 | 0.81 | FFAR1 (0.70) | ALDH1A1NAMPTLMNAGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271646-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |