Sugi Predict

Sugi Predict / Compounds / SCHEMBL1017425

SCHEMBL1017425

SCHEMBL1017425

O=C(O)C1CC1c1ccncc1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.57
▸ NAMPT P43490 2/20 0.57
▸ LMNA P02545 1/20 0.57
▸ GAA P10253 1/20 0.57
▸ HTT P42858 1/20 0.57
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ FFAR1 O14842 6/20 0.54
▸ HDAC4 P56524 1/20 0.46
▸ MAPT P10636 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ ROCK2 O75116 2/20 0.43
▸ SLC9A1 P19634 1/20 0.42
▸ GPR88 Q9GZN0 1/20 0.41
▸ CYP4F2 P78329 1/20 0.40
▸ CYP4A11 Q02928 1/20 0.40
▸ ITK Q08881 1/20 0.40
▸ HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1019296 1.00 ALDH1A1 (0.57) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL1017427 1.00 ALDH1A1 (0.57) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL1019924 0.84 ALDH1A1 (0.53) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL12765360 0.84 ALDH1A1 (0.53) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL1018424 0.84 ALDH1A1 (0.53) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL15219834 0.82 ALDH1A1 (0.51) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL30927243 0.82 ALDH1A1 (0.51) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL4126470 0.81 FFAR1 (0.70) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL5217474 0.81 FFAR1 (0.70) ALDH1A1NAMPTLMNAGAAHTT
SCHEMBL2034678 0.81 FFAR1 (0.70) ALDH1A1NAMPTLMNAGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12459956-B2 Heterobicyclic carboxamides and uses thereof ALCON INC. (CH) 2025-11-04 — — US disclosed
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 — — CN disclosed
EP-3568390-B1 SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST (US) 2024-03-06 — — EP disclosed
US-11806337-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2023-11-07 — — US disclosed
US-11806337-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2023-11-07 — — US disclosed
US-11806337-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2023-11-07 — — US disclosed
US-20230116770-A1 SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute 2023-04-13 — — US disclosed
US-20230002404-A1 HETEROBICYCLIC CARBOXAMIDES AND USES THEREOF ALCON INC. (CH) 2023-01-05 — — US disclosed
US-20230002404-A1 HETEROBICYCLIC CARBOXAMIDES AND USES THEREOF ALCON INC. (CH) 2023-01-05 — — US disclosed
US-11452717-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof Sanford Burnham Prebys Medical Discovery Institute (US) 2022-09-27 — — US disclosed
EP-2271646-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2011-01-12 — — EP disclosed
US-7795249-B2 Certain pyrazoline derivatives with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2010-09-14 — — US disclosed
US-7714136-B2 Tetrahydropyridothiophenes 4SC AG (DE) 2010-05-11 — — US disclosed
WO-2010031183-A1 INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS MERCK FROSST CANADA LTD. (CA) 2010-03-25 — — WO disclosed
EP-2125778-A1 CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY Millennium Pharmaceuticals, Inc. (US) 2009-12-02 — — EP disclosed
US-20090258873-A1 Novel tetrahydropyridothiophenes PEKARI KLAUS 2009-10-15 — — US disclosed
WO-2009123986-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-10-08 — — WO disclosed
US-20080206258-A1 Novel Tetrahydropyridothiophenes NYCOMED GMBH (DE) 2008-08-28 — — US disclosed
US-20080171754-A1 Certain pyrazoline derivatives with kinase inhibitory activity MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-07-17 — — US disclosed
WO-2008079277-A1 CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-07-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11452717-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof NAMPT, NAPRT, NNT ALDH1A1 1943/4885NAMPT 1/4885LMNA 2516/4885
US-20230002404-A1 HETEROBICYCLIC CARBOXAMIDES AND USES THEREOF UACA, PHKG2, CCAR2 ALDH1A1 3887/4885NAMPT 609/4885LMNA 2156/4885
US-20080206258-A1 Novel Tetrahydropyridothiophenes BAX, BCL2, CCAR2 ALDH1A1 615/4885NAMPT 877/4885LMNA 3874/4885
US-11806337-B2 Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof NAMPT, NAPRT, NNT ALDH1A1 1943/4885NAMPT 1/4885LMNA 2516/4885
US-20230116770-A1 SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF NAMPT, NAPRT, NNT ALDH1A1 1943/4885NAMPT 1/4885LMNA 2516/4885
US-20080171754-A1 Certain pyrazoline derivatives with kinase inhibitory activity MAP3K5, MAP4K5, MAP3K20 ALDH1A1 3584/4885NAMPT 1152/4885LMNA 2987/4885
US-12459956-B2 Heterobicyclic carboxamides and uses thereof UACA, PHKG2, CCAR2 ALDH1A1 3887/4885NAMPT 609/4885LMNA 2156/4885
US-20090258873-A1 Novel tetrahydropyridothiophenes BAX, BCL2, CCAR2 ALDH1A1 632/4885NAMPT 835/4885LMNA 4066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.