Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175124 | 0.87 | CYP11B2 (0.51) | CYP11B2CYP11B1CYP19A1ADRA2BALOX15 | |
| SCHEMBL17896646 | 0.82 | CYP11B1 (0.57) | CYP11B2CYP11B1CYP19A1ADRA2BCYP3A4 | |
| SCHEMBL17896647 | 0.80 | CYP11B2 (0.67) | CYP11B2CYP11B1HTTATM | |
| SCHEMBL10175145 | 0.79 | CYP11B2 (0.55) | CYP11B2CYP11B1CYP19A1ADRA2BALOX15 | |
| SCHEMBL17883792 | 0.75 | CYP11B2 (0.58) | CYP11B2CYP11B1CYP19A1ADRA2BALOX15 | |
| SCHEMBL17896599 | 0.75 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2BALOX15 | |
| SCHEMBL10176221 | 0.74 | KDM4E (0.52) | CYP11B2CYP11B1ALOX15HTTCA12 | |
| SCHEMBL16806047 | 0.73 | KDM4E (0.51) | CYP11B2CYP11B1ALOX15HTTATM | |
| SCHEMBL17896771 | 0.72 | CYP11B1 (0.54) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL17896648 | 0.72 | CYP11B2 (0.59) | CYP11B2CYP11B1ALOX15CYP3A4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |