Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 15/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 15/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462253 | 0.88 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP19A1ADRA2B | |
| SCHEMBL10175124 | 0.84 | CYP11B2 (0.51) | CYP11B1CYP11B2CYP19A1ADRA2BTLR7 | |
| SCHEMBL459881 | 0.81 | CYP11B2 (0.56) | CYP11B1CYP11B2 | |
| SCHEMBL17896612 | 0.78 | CYP11B2 (0.52) | CYP11B1CYP11B2CYP19A1ADRA2B | |
| SCHEMBL17896641 | 0.78 | CYP11B2 (0.47) | CYP11B1CYP11B2CYP19A1ADRA2BTLR7 | |
| SCHEMBL17896599 | 0.78 | CYP11B2 (0.63) | CYP11B1CYP11B2CYP19A1ADRA2B | |
| SCHEMBL17896619 | 0.76 | NPC1 (0.51) | CYP11B1CYP11B2CYP19A1ADRA2BTLR7 | |
| SCHEMBL462213 | 0.76 | CYP11B2 (0.55) | CYP11B1CYP11B2CYP19A1ADRA2B | |
| SCHEMBL17896718 | 0.74 | CYP11B2 (0.56) | CYP11B1CYP11B2CYP19A1ADRA2B | |
| SCHEMBL10175581 | 0.74 | CYP11B2 (0.71) | CYP11B1CYP11B2CYP19A1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |