Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896692 | 0.86 | CYP11B1 (0.46) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL17896687 | 0.86 | CYP11B1 (0.55) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL460358 | 0.84 | RAB9A (0.48) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL10176203 | 0.83 | CYP11B2 (0.69) | MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL17896689 | 0.83 | CYP11B2 (0.44) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL17883786 | 0.83 | CYP11B2 (0.46) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL747042 | 0.83 | CYP11B1 (0.43) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL17896694 | 0.82 | FGFR3 (0.49) | RAB9AMEN1KMT2AMAPTCYP11B1 | |
| SCHEMBL17896686 | 0.82 | CYP11B2 (0.71) | RAB9AMEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL10175359 | 0.81 | MEN1 (0.62) | RAB9AMEN1KMT2AMAPTCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |