Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175617 | 0.89 | CYP11B2 (0.55) | METMAPK10MAPTCYP17A1KDM4E | |
| SCHEMBL460529 | 0.85 | NAMPT (0.53) | METMAPK10CYP17A1FYNCYP11B1 | |
| SCHEMBL10175462 | 0.85 | KDM4E (0.42) | KDM4EHTTHDAC1HDAC8CYP11B1 | |
| SCHEMBL17897056 | 0.84 | MET (0.49) | METMAPK10MAPTCYP17A1HTT | |
| SCHEMBL17883790 | 0.80 | USP2 (0.63) | METMAPK10MAPTCYP17A1KDM4E | |
| SCHEMBL10175612 | 0.78 | CYP11B2 (0.63) | METMAPK10CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL17896765 | 0.74 | CYP11B2 (0.58) | MAPTKDM4EHTTCYP11B1CYP11B2 | |
| SCHEMBL17883783 | 0.73 | CYP11B2 (0.43) | MAPTKDM4EHTTCYP11B1CYP11B2 | |
| SCHEMBL10175134 | 0.73 | CYP11B1 (0.59) | HTTCYP11B1CYP11B2SMN1; SMN2CYP1A2 | |
| SCHEMBL14314688 | 0.72 | CYP11B2 (0.56) | MAPTKDM4ECYP11B1CYP11B2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |