Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 13/20 | 1.00 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175594 | 0.90 | CYP11B2 (0.81) | CYP11B2CYP11B1RPS6KA5CYP1A2CYP2C19 | |
| SCHEMBL17896586 | 0.87 | CYP11B2 (0.77) | CYP11B2CYP11B1CYP1A2CYP2C19TDP1 | |
| SCHEMBL17896590 | 0.86 | CYP11B2 (0.75) | CYP11B2CYP11B1CYP1A2CYP2C19TDP1 | |
| SCHEMBL10175584 | 0.85 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL10175585 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1 | |
| SCHEMBL10176164 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL12116699 | 0.82 | CYP11B2 (0.70) | CYP11B2CYP11B1RPS6KA5CYP1A2CYP2C19 | |
| SCHEMBL10175599 | 0.80 | CYP11B2 (0.66) | CYP11B2CYP11B1RPS6KA5 | |
| SCHEMBL10176165 | 0.80 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL20349192 | 0.77 | CYP11B2 (1.00) | CYP11B2CYP11B1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |