Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 12/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176167 | 0.89 | CYP11B2 (0.80) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL10176202 | 0.84 | CYP11B2 (0.73) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL8209154 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL17896686 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL30663914 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL10175581 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1MEN1KMT2A | |
| SCHEMBL10176165 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10175583 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10176203 | 0.82 | CYP11B2 (0.69) | CYP11B2CYP11B1MEN1KMT2A | |
| SCHEMBL1104859 | 0.81 | MEN1 (0.69) | CYP11B2CYP11B1ATMUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |