Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 17/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 14/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.66 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896587 | 0.84 | CYP11B2 (0.73) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10176164 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10175583 | 0.80 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10175587 | 0.79 | CYP11B2 (1.00) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10176228 | 0.77 | USP2 (0.70) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL460209 | 0.76 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL971842 | 0.76 | PDE10A (0.67) | CYP11B2CYP11B1PDE10A | |
| SCHEMBL10175584 | 0.75 | CYP11B2 (1.00) | CYP11B2CYP11B1 | |
| SCHEMBL10176167 | 0.75 | CYP11B2 (0.80) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10175131 | 0.74 | USP2 (0.65) | CYP11B2CYP11B1USP2HTTNCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |