SCHEMBL10176183

SCHEMBL10176183

CCC(C)Nc1cc(F)c(F)cc1[N+](=O)[O-]

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 7/20 0.58
ALDH1A1 P00352 4/20 0.55
CYP1A2 P05177 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
GLP1R P43220 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
MAPT P10636 3/20 0.38
KMT2A Q03164 1/20 0.38
GART P22102 1/20 0.38
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2967535 0.83 HCAR3 (0.53) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL11523263 0.83 ALDH1A1 (0.60) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL8810869 0.77 HCAR3 (0.68) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL10249259 0.77 HCAR3 (0.68) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL10249297 0.77 CYP3A4 (0.61) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL428455 0.77 HCAR3 (0.53) HCAR3ALDH1A1L3MBTL1GAAMAPT
SCHEMBL11576321 0.76 ALDH1A1 (0.74) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL5784069 0.76 MAPT (0.49) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL116464 0.76 MAPT (0.64) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL118610 0.76 HCAR3 (0.52) HCAR3ALDH1A1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012012478-A1 ALDOSTERONE SYNTHASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-01-26 WO disclosed