SCHEMBL8810869

SCHEMBL8810869

CCC(C)Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 5/20 0.68
CRHBP P24387 1/20 0.62
CRHR2 Q13324 1/20 0.62
ALDH1A1 P00352 5/20 0.54
L3MBTL1 Q9Y468 4/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
MAPT P10636 8/20 0.53
MAPK1 P28482 6/20 0.53
TDP1 Q9NUW8 4/20 0.53
SMN1; SMN2 Q16637 2/20 0.51
HTT P42858 1/20 0.51
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8673641 0.86 HCAR3 (0.66) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL10249259 0.85 HCAR3 (0.68) HCAR3ALDH1A1L3MBTL1CYP1A2CYP3A4
SCHEMBL10089736 0.84 CRHBP (0.68) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL9140856 0.83 CRHBP (0.60) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL31045644 0.82 CRHBP (0.52) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL12486687 0.82 CRHBP (0.52) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL6156984 0.81 CRHBP (0.65) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL6044169 0.81 HCAR3 (1.00) HCAR3MEN1KMT2A
SCHEMBL8742128 0.80 CRHBP (0.56) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1
SCHEMBL4301791 0.80 CRHBP (0.56) HCAR3CRHBPCRHR2ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5689006-A Process for producing n-alkyl-dinitroalkylanilines SRM CHEMICAL, LTD. CO. (US) 1997-11-18 US disclosed
US-5663441-A Production of mono-N-alkyl-dinitroalkylanilines and N-alkyl-dinitroaniline derivatives SRM CHEMICAL, LTD. CO. (US) 1997-09-02 US disclosed
WO-1997001527-A1 PRODUCTION OF MONO-N-ALKYL-DINITROALKYLANILINES AND N-ALKYL-DINITROANILINE DERIVATIVES SYNTECH LTD. CO. (US) 1997-01-16 WO disclosed
US-4395572-A Process for preparing N-alkyl-nitroanilines UNION CARBIDE CORPORATION (US) 1983-07-26 US disclosed
US-4289907-A Process for preparing N-alkyl-nitroanilines UNION CARBIDE CORPORATION (US) 1981-09-15 US disclosed