Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 5/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10177522 | 0.89 | CYP2A6 (0.45) | CYP2A6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15629928 | 0.85 | CYP2A6 (0.55) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL15629927 | 0.84 | SLC6A3 (0.70) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL5534970 | 0.84 | SLC6A2 (0.70) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL10178346 | 0.84 | CYP2A6 (0.54) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL16062591 | 0.84 | SLC6A3 (0.70) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL10178408 | 0.84 | SLC6A2 (0.70) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL10178387 | 0.84 | CYP2A6 (0.54) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL10178388 | 0.84 | CYP2A6 (0.54) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 | |
| SCHEMBL10178396 | 0.84 | SLC6A2 (0.70) | CYP2A6SLC6A2SLC6A4SLC6A3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067951-B2 | Process and intermediates for the production of CCR2 antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-30 | — | — | US | disclosed |
| US-20140336374-A1 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF CCR2 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-13 | — | — | US | disclosed |
| US-8835440-B2 | Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-16 | — | — | US | disclosed |
| US-20120053164-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053164-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | CCR2, CCR1, CCR5 | CYP2A6 1231/4885SLC6A2 3577/4885SLC6A4 3872/4885 |
| US-20140336374-A1 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF CCR2 ANTAGONISTS | CCR2, CCR5, CCR1 | CYP2A6 720/4885SLC6A2 3559/4885SLC6A4 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.