Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629076 | 0.82 | KDR (0.52) | KDRTGFBR1KDM4CMAPTSMN1; SMN2 | |
| SCHEMBL1460368 | 0.76 | KDR (1.00) | KDR | |
| SCHEMBL11983623 | 0.74 | CCR1 (0.57) | KDRKDM4CPIM1MEN1KMT2A | |
| SCHEMBL1461475 | 0.73 | KDR (1.00) | KDR | |
| SCHEMBL20748504 | 0.72 | KDM4C (0.49) | KDRKDM4CMAPTHPGDMEN1 | |
| SCHEMBL20748703 | 0.72 | KDR (0.56) | KDRKDM4CMAPTALOX15MAPKAPK2 | |
| SCHEMBL13829512 | 0.69 | ACHE (0.46) | KDRSMN1; SMN2HPGDPIM1NISCH | |
| SCHEMBL1460341 | 0.68 | KDM4C (0.50) | KDRKDM4CMAPKAPK2 | |
| SCHEMBL12203789 | 0.68 | CYP3A4 (0.45) | MAPTSMN1; SMN2NPSR1ALOX15HPGD | |
| SCHEMBL4864306 | 0.67 | MAPKAPK2 (0.41) | KDRTGFBR1KDM4CPIM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473501-A1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | Allergan, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |