Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460341 | 0.86 | KDM4C (0.50) | KDM4CKDRMAP4K4ASIC3NTRK1 | |
| SCHEMBL20748703 | 0.78 | KDR (0.56) | KDM4CKDRNTRK1ALDH1A1MAPT | |
| SCHEMBL6521352 | 0.78 | KDR (0.51) | KDM4CKDRMEN1ALDH1A1MAPT | |
| SCHEMBL30469333 | 0.78 | MAOA (0.50) | MAP4K4METAP2MEN1PSIP1AXL | |
| SCHEMBL16236283 | 0.78 | MAOA (0.50) | MAP4K4METAP2MEN1PSIP1AXL | |
| SCHEMBL28511258 | 0.77 | MAOA (0.55) | MAP4K4METAP2MEN1PSIP1AXL | |
| SCHEMBL10179472 | 0.72 | KDR (0.61) | KDM4CKDRMEN1NPC1RAB9A | |
| SCHEMBL28687161 | 0.72 | ASIC3 (0.54) | MAP4K4ASIC3MEN1PSIP1AXL | |
| SCHEMBL30880192 | 0.72 | ASIC3 (0.54) | MAP4K4ASIC3MEN1PSIP1AXL | |
| SCHEMBL2686693 | 0.71 | MAP4K4 (0.58) | MAP4K4ASIC3MEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473501-B1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | ALLERGAN INC (US) | 2019-02-20 | — | — | EP | disclosed |