Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 15/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | RPS27 | P42677 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.36 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965134 | 0.91 | ADORA1 (0.38) | MAPK8MAPK9MAPK10ADORA1ADORA2A | |
| SCHEMBL10180844 | 0.89 | MAPK8 (0.43) | MAPK8MAPK9PRKD3MAPK10PRKD2 | |
| SCHEMBL10180598 | 0.86 | MAPK8 (0.45) | MAPK8MAPK9PRKD3MAPK10PRKD2 | |
| SCHEMBL10180469 | 0.85 | MEN1 (0.41) | ADORA1ADORA2A | |
| SCHEMBL12946926 | 0.84 | MAPK8 (0.42) | MAPK8MAPK9PRKD3MAPK10PRKD2 | |
| SCHEMBL10180545 | 0.82 | MAPK8 (0.41) | MAPK8MAPK9PRKD3MAP4K4MAP4K2 | |
| SCHEMBL12947084 | 0.81 | MAPK8 (0.43) | MAPK8MAPK9PRKD3MAPK10PRKD2 | |
| SCHEMBL10180785 | 0.79 | PIK3CD (0.37) | MAPK8MAPK9POLQ | |
| SCHEMBL10180692 | 0.76 | MAPK8 (0.38) | MAPK8MAPK9PRKD3MAPK10ADORA1 | |
| SCHEMBL10180176 | 0.76 | MAPK8 (0.38) | MAPK8MAPK9PRKD3MAPK10PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |