Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.36 |
| ▸ | POLQ | O75417 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180844 | 0.94 | MAPK8 (0.43) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10180785 | 0.89 | PIK3CD (0.37) | MAPK8MAPK9POLQMAPTLMNA | |
| SCHEMBL10327478 | 0.84 | ALDH1A1 (0.42) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL3459373 | 0.84 | MAPK8 (0.42) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10180924 | 0.82 | MAPK8 (0.42) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10181273 | 0.81 | PIK3CD (0.37) | MAPK8MAPK9POLQALDH1A1CTSK | |
| SCHEMBL10180598 | 0.81 | MAPK8 (0.45) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10180176 | 0.81 | MAPK8 (0.38) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL3459370 | 0.81 | ALDH1A1 (0.43) | MAPK8PRKD3MAP4K4MAP4K2PKN2 | |
| SCHEMBL10180401 | 0.79 | RXFP1 (0.44) | ALDH1A1MAPTCTSKPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |