Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 16/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946848 | 0.94 | TRPV4 (0.48) | TRPV4EPHX2KMT2ACASR | |
| SCHEMBL10180493 | 0.92 | TRPV4 (0.42) | TRPV4EPHX2KMT2ACASR | |
| SCHEMBL10181524 | 0.88 | TRPV4 (0.46) | TRPV4EPHX2KMT2ACTSKKCNH2 | |
| SCHEMBL964364 | 0.87 | KMT2A (0.45) | TRPV4KMT2ACTSK | |
| SCHEMBL10327259 | 0.87 | TRPV4 (0.49) | TRPV4EPHX2KMT2ACASR | |
| SCHEMBL3459382 | 0.86 | HPGD (0.44) | TRPV4KMT2ACTSK | |
| SCHEMBL964828 | 0.86 | HPGD (0.44) | TRPV4KMT2ACTSK | |
| SCHEMBL12946845 | 0.86 | TRPV4 (0.44) | TRPV4EPHX2KMT2A | |
| SCHEMBL10180841 | 0.84 | KMT2A (0.43) | TRPV4KMT2ACTSK | |
| SCHEMBL966008 | 0.84 | KMT2A (0.42) | KMT2ACTSKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |