Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946852 | 0.95 | TRPV4 (0.47) | TRPV4EPHX2MAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL10180028 | 0.92 | MAPK8 (0.45) | TRPV4EPHX2MAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL10181357 | 0.88 | TRPV4 (0.47) | TRPV4EPHX2KMT2AKCNH2CTSK | |
| SCHEMBL968116 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9KMT2AMEN1NPSR1 | |
| SCHEMBL963869 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9KMT2AMEN1NPSR1 | |
| SCHEMBL12946985 | 0.86 | MAPK8 (0.45) | TRPV4EPHX2MAPK8MAPK9KMT2A | |
| SCHEMBL10180583 | 0.85 | TRPV4 (0.42) | TRPV4EPHX2KMT2AKCNH2SLC6A2 | |
| SCHEMBL965756 | 0.84 | MAPK8 (0.41) | MAPK8MAPK9SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL968112 | 0.84 | MAPK8 (0.37) | MAPK8MAPK9KMT2AMEN1CYP3A4 | |
| SCHEMBL3460790 | 0.84 | MAPK8 (0.41) | MAPK8MAPK9SMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |