Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10181136 | 0.92 | MAPK8 (0.47) | TRPV4EPHX2MAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL10180610 | 0.88 | TRPV4 (0.49) | TRPV4EPHX2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5568817 | 0.87 | ALDH1A1 (0.40) | MAPK8MAPK9SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL964165 | 0.86 | ALDH1A1 (0.39) | MAPK8MAPK9KMT2AMEN1NPSR1 | |
| SCHEMBL10182156 | 0.86 | TRPV4 (0.45) | TRPV4EPHX2MAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL10181159 | 0.85 | TRPV4 (0.45) | TRPV4EPHX2KMT2AMEN1THRB | |
| SCHEMBL964886 | 0.84 | POLB (0.37) | MAPK8MAPK9KMT2AMEN1NPSR1 | |
| SCHEMBL967116 | 0.84 | RXFP1 (0.40) | TRPV4MAPK8MAPK9KMT2AMEN1 | |
| SCHEMBL1010116 | 0.84 | POLB (0.40) | MAPK8MAPK9KMT2AMEN1NPSR1 | |
| SCHEMBL965940 | 0.84 | ALDH1A1 (0.42) | MAPK8MAPK9SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |