Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 6/20 | 0.48 |
| ▸ | CA9 | Q16790 | 6/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10590325 | 0.89 | SMN1; SMN2 (0.64) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL12472341 | 0.85 | CA12 (0.61) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL8982627 | 0.82 | CA12 (0.61) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL19617695 | 0.81 | TSHR (0.62) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL10944695 | 0.81 | SMN1; SMN2 (0.62) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL5724579 | 0.78 | TSHR (0.68) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL7208440 | 0.77 | CA2 (0.44) | CA2ALDH1A1 | |
| SCHEMBL11797264 | 0.77 | SMN1; SMN2 (0.66) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL2576800 | 0.77 | SMN1; SMN2 (0.66) | CA2TSHRSMN1; SMN2CA1MMP1 | |
| SCHEMBL7189936 | 0.77 | SMN1; SMN2 (0.66) | CA2TSHRSMN1; SMN2CA1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458447-B1 | PIPERAZINYL METHANONE NAAA INHIBITORS | UNIV CALIFORNIA (US) | 2023-11-29 | — | — | EP | disclosed |
| CN-109476616-B | Piperazinyl methanone NAAA inhibitors | 加利福尼亚大学董事会 | 2023-10-13 | — | — | CN | disclosed |
| US-10556892-B2 | Piperazinyl methanone NAAA inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190177313-A1 | PIPERZINYL METHANONE NAAA INHIBITORS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2019-06-13 | — | — | US | disclosed |
| EP-3458447-A1 | PIPERAZINYL METHANONE NAAA INHIBITORS | The Regents of The University of California (US) | 2019-03-27 | — | — | EP | disclosed |
| CN-109476616-A | Piperazinyl methanone NAAA inhibitor | 加利福尼亚大学董事会 | 2019-03-15 | — | — | CN | disclosed |
| WO-2017201103-A1 | PIPERAZINYL METHANONE NAAA INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-23 | — | — | WO | disclosed |
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| EP-1789390-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177313-A1 | PIPERZINYL METHANONE NAAA INHIBITORS | NAAA, NAA15, NAA50 | CA2 2876/4885TSHR 4460/4885SMN1; SMN2 576/4885 |
| US-10556892-B2 | Piperazinyl methanone NAAA inhibitors | NAAA, NAA50, NAA15 | CA2 2959/4885TSHR 4247/4885SMN1; SMN2 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.