Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GUCY1A1 | Q02108 | 12/20 | 0.44 |
| ▸ | GUCY1B1 | Q02153 | 12/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183175 | 0.87 | KEAP1 (0.61) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL15167596 | 0.86 | GUCY1A1 (0.62) | KEAP1NFE2L2POLBMAPTKDM4E | |
| SCHEMBL27799338 | 0.86 | KEAP1 (0.57) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL4389379 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2KDM4EALDH1A1GUCY1A1 | |
| SCHEMBL27799412 | 0.78 | KEAP1 (0.59) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL4001274 | 0.77 | KEAP1 (0.58) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL18734060 | 0.77 | KEAP1 (0.73) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL3997434 | 0.76 | KEAP1 (0.57) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL3994663 | 0.76 | KEAP1 (0.68) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL15168665 | 0.76 | GUCY1A1 (0.60) | KEAP1NFE2L2POLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058132-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |