Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.59 |
| ▸ | GUCY1A1 | Q02108 | 10/20 | 0.51 |
| ▸ | GUCY1B1 | Q02153 | 10/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780167 | 0.85 | GUCY1A1 (0.71) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL3997434 | 0.82 | KEAP1 (0.57) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL20847835 | 0.80 | KEAP1 (0.56) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL27799338 | 0.79 | KEAP1 (0.57) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL17397561 | 0.79 | GUCY1A1 (0.79) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL3994637 | 0.78 | KEAP1 (0.73) | KEAP1NFE2L2POLBMAPTSMN1; SMN2 | |
| SCHEMBL4001274 | 0.78 | KEAP1 (0.58) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL3995012 | 0.78 | KEAP1 (0.66) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL10182607 | 0.78 | KEAP1 (0.59) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB | |
| SCHEMBL3992406 | 0.77 | KEAP1 (0.68) | KEAP1NFE2L2GUCY1A1GUCY1B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101939053-A | Soluble guanylate cyclase activators | MERCK SHARP & DOHME | 2011-01-05 | — | — | CN | disclosed |