Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 3/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10184034 | 0.88 | CCKBR (0.36) | OPRM1OPRK1OPRL1CCKBRAGTR2 | |
| SCHEMBL10183329 | 0.88 | CCKBR (0.36) | OPRM1OPRK1OPRL1CCKBRAGTR2 | |
| SCHEMBL10183299 | 0.87 | OPRM1 (0.40) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183802 | 0.86 | OPRM1 (0.38) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10185957 | 0.86 | TSHR (0.43) | OPRM1OPRK1OPRL1IDH1KMT2A | |
| SCHEMBL10183337 | 0.86 | OPRM1 (0.39) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183319 | 0.86 | MEN1 (0.43) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10185857 | 0.86 | SLC6A2 (0.38) | OPRM1OPRK1OPRL1MAPT | |
| SCHEMBL10183638 | 0.85 | OPRM1 (0.35) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183666 | 0.84 | OPRM1 (0.39) | OPRM1OPRK1OPRL1AGTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |