Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460109 | 0.86 | RAB9A (0.65) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL12302080 | 0.84 | MEN1 (0.58) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL14817937 | 0.84 | MEN1 (0.58) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL12302079 | 0.84 | MEN1 (0.58) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL14972572 | 0.83 | ATM (0.51) | RAB9ANPC1KMT2AALDH1A1HPGD | |
| SCHEMBL3652877 | 0.83 | ATM (0.51) | RAB9ANPC1KMT2AALDH1A1HPGD | |
| SCHEMBL31432824 | 0.82 | ALDH1A1 (0.71) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL3380039 | 0.81 | RAB9A (0.65) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL12019757 | 0.81 | RAB9A (0.65) | HDAC4HDAC6RAB9ANPC1KMT2A | |
| SCHEMBL6068898 | 0.81 | HPGD (0.68) | RAB9ANPC1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |