Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NAMPT | P43490 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753673 | 0.83 | HPGD (0.68) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL15489278 | 0.82 | HPGD (0.66) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL1018356 | 0.81 | HDAC4 (0.52) | HPGDRAB9AALDH1A1HTTMEN1 | |
| SCHEMBL13753672 | 0.81 | HPGD (0.65) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL2976653 | 0.81 | MLYCD (0.59) | HPGDALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3033950 | 0.81 | HPGD (0.64) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL18403112 | 0.79 | HPGD (0.58) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL2317132 | 0.78 | HPGD (0.66) | HPGDRAB9AALDH1A1HTTMEN1 | |
| SCHEMBL14864017 | 0.78 | HPGD (0.60) | HPGDRAB9AALDH1A1HTTNAMPT | |
| SCHEMBL4496787 | 0.78 | HDAC1 (0.61) | HPGDRAB9AALDH1A1HTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071219-B2 | Mono-acylated o-phenylendiamines derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-07-04 | — | — | US | disclosed |