Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185587 | 0.94 | TRPM8 (0.41) | TRPM8LMNASMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL10184008 | 0.91 | PTGIR (0.38) | TRPM8SMN1; SMN2OPRM1OPRK1OPRL1 | |
| SCHEMBL10184119 | 0.89 | OPRM1 (0.37) | TRPM8LMNAOPRM1OPRK1OPRL1 | |
| SCHEMBL10185551 | 0.88 | NPC1 (0.37) | TRPM8LMNASMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL10183973 | 0.87 | TRPM8 (0.38) | TRPM8LMNASMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL10183299 | 0.87 | OPRM1 (0.40) | LMNAOPRM1OPRK1OPRL1CCKBR | |
| SCHEMBL10183337 | 0.86 | OPRM1 (0.39) | LMNAOPRM1OPRK1OPRL1CCKBR | |
| SCHEMBL10183319 | 0.86 | MEN1 (0.43) | LMNASMN1; SMN2OPRM1OPRK1OPRL1 | |
| SCHEMBL10183638 | 0.85 | OPRM1 (0.35) | LMNAOPRM1OPRK1OPRL1CCKBR | |
| SCHEMBL10183683 | 0.85 | OPRM1 (0.35) | TRPM8LMNAOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |