Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183761 | 0.91 | TRPM8 (0.42) | TRPM8TP53ALDH1A1OPRM1OPRK1 | |
| SCHEMBL10185587 | 0.89 | TRPM8 (0.41) | PTGIRTRPM8ALDH1A1OPRM1OPRK1 | |
| SCHEMBL10183973 | 0.87 | TRPM8 (0.38) | TRPM8ALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL10185957 | 0.86 | TSHR (0.43) | PTGIRUSP2TSHRTP53KDM4E | |
| SCHEMBL10185551 | 0.86 | NPC1 (0.37) | TRPM8KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL10184119 | 0.83 | OPRM1 (0.37) | PTGIRTRPM8TP53CYP1A2CYP3A4 | |
| SCHEMBL10185933 | 0.83 | GRM5 (0.40) | PTGIRUSP2TSHRKDM4EOPRM1 | |
| SCHEMBL10185558 | 0.83 | NPC1 (0.36) | PTGIRTSHRKDM4EALDH1A1OPRM1 | |
| SCHEMBL10183676 | 0.82 | HCRTR1 (0.35) | TRPM8OPRM1OPRK1OPRL1MAPT | |
| SCHEMBL10183299 | 0.82 | OPRM1 (0.40) | PTGIRTP53OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |