Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183227 | 0.91 | MAPT (0.42) | HTR1ADRD2HTR2AMAPTMEN1 | |
| SCHEMBL10185957 | 0.83 | TSHR (0.43) | MAPTKMT2AUSP2KDM4ETSHR | |
| SCHEMBL10185553 | 0.82 | CYP3A4 (0.34) | HTR1ADRD2HTR2AMAPTMEN1 | |
| SCHEMBL10184008 | 0.80 | PTGIR (0.38) | MAPTUSP2KDM4ETSHROPRM1 | |
| SCHEMBL10183299 | 0.79 | OPRM1 (0.40) | MAPTOPRM1OPRK1OPRL1IDH1 | |
| SCHEMBL10183319 | 0.79 | MEN1 (0.43) | MAPTMEN1KMT2AKDM4EOPRM1 | |
| SCHEMBL10183337 | 0.79 | OPRM1 (0.39) | MAPTMEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL10185857 | 0.78 | SLC6A2 (0.38) | MAPTKDM4EOPRM1OPRK1OPRL1 | |
| SCHEMBL10183925 | 0.78 | TP53 (0.41) | MAPTMEN1KMT2AKDM4ETSHR | |
| SCHEMBL10183321 | 0.78 | OPRM1 (0.37) | MAPTMEN1KMT2AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |