Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | CCKBR | P32239 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183694 | 0.88 | OPRM1 (0.41) | OPRM1OPRK1OPRL1ALDH1A1CCKBR | |
| SCHEMBL10183939 | 0.87 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1CCKBR | |
| SCHEMBL10185977 | 0.85 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1CCKBR | |
| SCHEMBL10183343 | 0.77 | KMT2A (0.36) | OPRM1OPRK1OPRL1CCKBRKMT2A | |
| SCHEMBL15137852 | 0.77 | OPRM1 (0.38) | OPRM1OPRK1OPRL1CCKBRMAPT | |
| SCHEMBL10183782 | 0.74 | OPRM1 (0.40) | OPRM1OPRK1OPRL1CCKBRMAPT | |
| SCHEMBL10183927 | 0.73 | OPRM1 (0.36) | OPRM1OPRK1OPRL1CCKBRMEN1 | |
| SCHEMBL10184071 | 0.73 | OPRM1 (0.37) | OPRM1OPRK1OPRL1CCKBRMAPT | |
| SCHEMBL10184157 | 0.72 | MAPT (0.38) | OPRM1OPRK1OPRL1ALDH1A1KMT2A | |
| SCHEMBL10183654 | 0.71 | IDH1 (0.38) | OPRM1OPRK1OPRL1CCKBRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |