Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | CCKBR | P32239 | 3/20 | 0.38 |
| ▸ | CCKAR | P32238 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185977 | 0.91 | OPRM1 (0.39) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183939 | 0.91 | OPRM1 (0.39) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183935 | 0.88 | OPRM1 (0.41) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183343 | 0.82 | KMT2A (0.36) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL15137852 | 0.82 | OPRM1 (0.38) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183782 | 0.79 | OPRM1 (0.40) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183669 | 0.79 | CCKBR (0.41) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10184157 | 0.79 | MAPT (0.38) | OPRM1OPRK1OPRL1CCR3ALDH1A1 | |
| SCHEMBL10184071 | 0.78 | OPRM1 (0.37) | OPRM1OPRK1OPRL1CCKBRCCKAR | |
| SCHEMBL10183740 | 0.77 | CYP3A4 (0.40) | OPRM1OPRK1OPRL1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |