Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183927 | 0.90 | OPRM1 (0.36) | MAPTLMNAKMT2AOPRM1OPRK1 | |
| SCHEMBL10183740 | 0.88 | CYP3A4 (0.40) | LMNAKMT2AOPRM1OPRK1OPRL1 | |
| SCHEMBL10183669 | 0.87 | CCKBR (0.41) | MAPTLMNAKMT2AOPRM1OPRK1 | |
| SCHEMBL10185977 | 0.86 | OPRM1 (0.39) | MAPTLMNAKMT2AOPRM1OPRK1 | |
| SCHEMBL10183782 | 0.86 | OPRM1 (0.40) | MAPTLMNAOPRM1OPRK1OPRL1 | |
| SCHEMBL10183924 | 0.86 | OPRK1 (0.38) | MAPTLMNAKMT2AOPRM1OPRK1 | |
| SCHEMBL10183654 | 0.83 | IDH1 (0.38) | MAPTLMNAOPRM1OPRK1OPRL1 | |
| SCHEMBL10184071 | 0.83 | OPRM1 (0.37) | MAPTLMNAOPRM1OPRK1OPRL1 | |
| SCHEMBL10185838 | 0.83 | NPC1 (0.35) | MAPTLMNAOPRM1OPRK1OPRL1 | |
| SCHEMBL10183289 | 0.82 | KMT2A (0.43) | KMT2AOPRM1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |