Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | PTGIR | P43119 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185933 | 0.87 | GRM5 (0.40) | PTGIRUSP2KDM4EAGTR2TSHR | |
| SCHEMBL10185907 | 0.85 | OPRM1 (0.35) | PTGIRUSP2KDM4EAGTR2OPRM1 | |
| SCHEMBL10185558 | 0.83 | NPC1 (0.36) | PTGIRKDM4EAGTR2TSHROPRM1 | |
| SCHEMBL10183638 | 0.83 | OPRM1 (0.35) | PTGIRAGTR2OPRM1OPRK1OPRL1 | |
| SCHEMBL10184008 | 0.82 | PTGIR (0.38) | PTGIRUSP2KDM4ETSHROPRM1 | |
| SCHEMBL10183973 | 0.80 | TRPM8 (0.38) | AGTR2OPRM1OPRK1OPRL1TRPM8 | |
| SCHEMBL10183676 | 0.80 | HCRTR1 (0.35) | AGTR2OPRM1OPRK1OPRL1TRPM8 | |
| SCHEMBL10184119 | 0.79 | OPRM1 (0.37) | PTGIRAGTR2OPRM1OPRK1OPRL1 | |
| SCHEMBL10185957 | 0.79 | TSHR (0.43) | PTGIRUSP2KDM4ETSHROPRM1 | |
| SCHEMBL10185551 | 0.79 | NPC1 (0.37) | KDM4EAGTR2OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |