Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 9/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.35 |
| ▸ | FLT4 | P35916 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588757 | 0.86 | KDR (0.39) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10188172 | 0.80 | TUBB4A (0.34) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28668261 | 0.78 | SLC22A12 (0.41) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL6998291 | 0.75 | MAPK14 (0.40) | KDRHDAC1HDAC6FLT1FLT4 | |
| SCHEMBL15514096 | 0.73 | RXRA (0.39) | KDRKITPDGFRAHDAC1HDAC6 | |
| SCHEMBL588522 | 0.72 | KDR (0.38) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15514657 | 0.72 | RXRA (0.41) | KDRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL589205 | 0.71 | KDR (0.68) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5227351 | 0.71 | KDR (0.44) | KDRCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12975335 | 0.71 | AAK1 (0.33) | MAP2K4AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277258-A1 | Chemical Compounds | LEO OSPREY LIMITED (JE) | 2012-11-01 | — | — | US | disclosed |
| US-8114885-B2 | Pazopanib hydrochloride and synthesis, chemical intermediates, and dosage forms thereof; anticancer; colon cancer, breast cancer | GLAXOSMITHKLINE LLC (US) | 2012-02-14 | — | — | US | disclosed |
| US-7858626-B2 | Pyrimidineamines as angiogenesis modulators | GLAXOSMITHKLINE LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100105712-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105712-A1 | CHEMICAL COMPOUNDS | KDR, FLT4, FLT1 | KDR 1/4885CYP3A4 2882/4885CYP2D6 1791/4885 |
| US-20120277258-A1 | Chemical Compounds | KDR, FLT4, FLT1 | KDR 1/4885CYP3A4 2882/4885CYP2D6 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.