Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638766 | 0.85 | ROCK2 (0.42) | SLC22A12CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL28336523 | 0.81 | SLC22A12 (0.36) | SLC22A12CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL10187295 | 0.78 | KDR (0.42) | AURKALIMK1TAOK1RXRARXRB | |
| SCHEMBL15514657 | 0.73 | RXRA (0.41) | AURKAMAPTRAB9ARXRARXRB | |
| SCHEMBL15639911 | 0.73 | ROCK2 (0.42) | SLC22A12CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL5227351 | 0.73 | KDR (0.44) | AURKACSNK1A1TAOK1CLK4RAB9A | |
| SCHEMBL12185524 | 0.72 | KDR (0.39) | MAPTKMT2ARAB9ANPC1MEN1 | |
| SCHEMBL15514096 | 0.72 | RXRA (0.39) | AURKARXRARXRBHDAC3HDAC1 | |
| SCHEMBL17025789 | 0.72 | CDC7 (0.48) | SLC22A12CHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL27925382 | 0.71 | RXRA (0.38) | AURKARXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113773308-A | RHO kinase inhibitors | 卡德门企业有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-113637008-A | RHO kinase inhibitors | 卡德门企业有限公司 | 2021-11-12 | — | — | CN | disclosed |
| CN-113637007-A | RHO kinase inhibitors | 卡德门企业有限公司 | 2021-11-12 | — | — | CN | disclosed |
| CN-113620933-A | RHO kinase inhibitors | 卡德门企业有限公司 | 2021-11-09 | — | — | CN | disclosed |