SCHEMBL10187595

SCHEMBL10187595

CCc1cc(Oc2ccc(Cl)cc2)ccc1C1=C(O)[C@H]2[C@@H](C1=O)[C@@H]1CC[C@H]2O1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.33
PPARG P37231 2/20 0.33
S1PR5 Q9H228 1/20 0.32
LMNA P02545 1/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
TNK2 Q07912 2/20 0.32
DRD2 P14416 1/20 0.32
PPARA Q07869 1/20 0.31
HTR2A P28223 1/20 0.31
SLC6A4 P31645 1/20 0.31
KCNH2 Q12809 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CTSD P07339 1/20 0.31
BACE1 P56817 1/20 0.31
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
MMP1 P03956 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10196000 0.92 MAOA (0.34) ELANEPPARGS1PR5MAOAMAOB
SCHEMBL19070661 0.92 MAOA (0.34) ELANEPPARGS1PR5MAOAMAOB
SCHEMBL10187644 0.85 PDE4B (0.33) PDE4B
SCHEMBL10196085 0.83 NAAA (0.35) HTR2ASLC6A4KCNH2MMP1MMP13
SCHEMBL19070649 0.83 NAAA (0.35) HTR2ASLC6A4KCNH2MMP1MMP13
SCHEMBL10196179 0.82 SLC6A4 (0.35) HTR2ASLC6A4KCNH2CTSDBACE1
SCHEMBL10196169 0.81 FFAR1 (0.38) LMNAHTR2ASLC6A4KCNH2ALDH1A1
SCHEMBL10196175 0.81 LTB4R (0.33) PPARGMAOAMAOBPPARAPDE4A
SCHEMBL10196100 0.81 MAOA (0.36) MAOAMAOB
SCHEMBL19070977 0.81 MAOA (0.36) MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 US disclosed
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 US disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 US disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 US disclosed
WO-2010089210-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-08-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120028800-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 ELANE 4611/4885PPARG 101/4885S1PR5 4209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.