Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 10/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379764 | 0.88 | SYK (0.55) | FGFR4SYKFLT3CDK4CCND1 | |
| SCHEMBL1017621 | 0.88 | SYK (0.55) | FGFR4SYKFLT3CDK4CCND1 | |
| SCHEMBL1018605 | 0.80 | FGFR4 (0.42) | FGFR4SYKFLT3CA2CA1 | |
| SCHEMBL1021471 | 0.77 | PTK2 (0.47) | SYKJAK2JAK3PTK2BRD4 | |
| SCHEMBL4393127 | 0.73 | L3MBTL1 (0.41) | CDK1KDRCA2CDK4CDK2 | |
| SCHEMBL1015796 | 0.73 | L3MBTL1 (0.41) | CDK1KDRCA2CDK4CDK2 | |
| SCHEMBL14547910 | 0.73 | KCNH3 (0.48) | FGFR4SYKCDK1KDRCA2 | |
| SCHEMBL4723463 | 0.73 | MAPT (0.41) | FGFR4SYKCDK1KDRCA2 | |
| SCHEMBL4410271 | 0.73 | FGFR4 (0.59) | FGFR4JAK2JAK3PTK2 | |
| SCHEMBL4764792 | 0.72 | CA1 (0.40) | SYKFLT3CDK1KDRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |