Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764792 | 0.92 | CA1 (0.40) | MAPTMEN1KMT2AKCNH3CA1 | |
| SCHEMBL14547910 | 0.89 | KCNH3 (0.48) | KCNH3CA1CA2CA9CDK1 | |
| SCHEMBL14547715 | 0.89 | KMT2A (0.45) | MAPTMEN1KMT2ARAB9ACA2 | |
| SCHEMBL4777744 | 0.84 | LRRK2 (0.44) | MAPTMEN1KMT2ATDP1SMN1; SMN2 | |
| SCHEMBL28991439 | 0.79 | ALDH1A1 (0.45) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL5113381 | 0.77 | L3MBTL1 (0.45) | MEN1KMT2ACA1CA2L3MBTL1 | |
| SCHEMBL5123488 | 0.77 | L3MBTL1 (0.45) | MEN1KMT2ACA1CA2L3MBTL1 | |
| SCHEMBL4843165 | 0.76 | LRRK2 (0.54) | LRRK2KDRAURKASYKCDK5 | |
| SCHEMBL5124617 | 0.76 | PTK2 (0.50) | MAPTTDP1LRRK2KDRAURKA | |
| SCHEMBL5114610 | 0.76 | PTK2 (0.46) | LRRK2CDK1CDK2KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948659-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |