Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10190438 | 0.86 | KMT2A (0.49) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL10190437 | 0.84 | KMT2A (0.68) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL10189645 | 0.83 | L3MBTL1 (0.62) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL16962841 | 0.77 | ALDH1A1 (0.55) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL17018756 | 0.73 | ALDH1A1 (0.55) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL16962878 | 0.73 | KCNH2 (0.71) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL18902090 | 0.73 | KMT2A (0.70) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL13151110 | 0.73 | PTPN2 (0.53) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL16962172 | 0.72 | KCNH2 (0.71) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL16962118 | 0.71 | ALDH1A1 (0.67) | KMT2AMAPTMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | KMT2A 1523/4885MAPT 2648/4885MEN1 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.