Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.61 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189107 | 0.75 | DGAT1 (0.86) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10189566 | 0.75 | DGAT1 (0.77) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10189573 | 0.74 | DGAT1 (0.55) | DGAT1SOAT1KDM4ENPC1ALDH1A1 | |
| SCHEMBL1687855 | 0.73 | DGAT1 (0.60) | DGAT1SOAT1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13163415 | 0.71 | DGAT1 (0.44) | DGAT1SOAT1TLR9TLR8TLR7 | |
| SCHEMBL10189113 | 0.70 | DGAT1 (0.64) | DGAT1SOAT1 | |
| SCHEMBL902462 | 0.70 | DGAT1 (0.73) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL14434976 | 0.69 | GRM5 (0.55) | — | |
| SCHEMBL10326022 | 0.69 | CHEK2 (0.54) | DGAT1SOAT1MAPTSMN1; SMN2ACHE | |
| SCHEMBL10189571 | 0.69 | DGAT1 (0.40) | DGAT1SOAT1TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |