Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 6/20 | 0.38 |
| ▸ | ME2 | P23368 | 4/20 | 0.37 |
| ▸ | ME1 | P48163 | 4/20 | 0.37 |
| ▸ | ME3 | Q16798 | 4/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684559 | 0.92 | OPRD1 (0.40) | SCNN1AHSD17B10KDM4EALDH1A1GLA | |
| SCHEMBL1684543 | 0.92 | SCNN1A (0.41) | SCNN1AME2ME1ME3HSD17B10 | |
| SCHEMBL1586606 | 0.89 | SCNN1A (0.34) | SCNN1AHSD11B1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL2126510 | 0.89 | NPC1 (0.35) | SCNN1AME2ME1ME3HSD11B1 | |
| SCHEMBL1684512 | 0.88 | KCNH2 (0.42) | GAAPLAUOPRD1TP53 | |
| SCHEMBL12215593 | 0.87 | GHSR (0.36) | SCNN1AHSD17B10ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1684677 | 0.87 | SCNN1A (0.34) | SCNN1AHSD17B10KDM4EALDH1A1GLA | |
| SCHEMBL12215560 | 0.86 | ALDH1A1 (0.38) | SCNN1AHSD17B10KDM4EALDH1A1GLA | |
| SCHEMBL2142417 | 0.86 | SCNN1A (0.37) | SCNN1APANK3OPRD1 | |
| SCHEMBL13321376 | 0.85 | GHSR (0.37) | SCNN1APANK3OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520574-A1 | Amiloride analogues substituted on the cyclic guanidine moiety as ENaC blockers for treating respiratory diseases | Novartis AG (CH) | 2012-11-07 | — | — | EP | disclosed |
| EP-2444120-A1 | Spirocyclic amiloride analogues as ENac blockers | Novartis AG (CH) | 2012-04-25 | — | — | EP | disclosed |