Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 9/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.44 |
| ▸ | DPP4 | P27487 | 6/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NPY4R | P50391 | 3/20 | 0.36 |
| ▸ | NPY1R | P25929 | 2/20 | 0.36 |
| ▸ | NPY2R | P49146 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.36 |
| ▸ | CLPP | Q16740 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL607606 | 0.99 | DPP7 (0.43) | DPP7DPP9DPP8DPP4NOS1 | |
| SCHEMBL14535404 | 0.91 | NOS1 (0.39) | DPP7DPP9DPP8DPP4NOS1 | |
| SCHEMBL3164624 | 0.85 | LONP1 (0.39) | PSMB5CLPP | |
| SCHEMBL3164228 | 0.83 | PSMB5 (0.47) | PSMB5CLPP | |
| SCHEMBL12754447 | 0.83 | LONP1 (0.39) | PSMB5CLPP | |
| SCHEMBL3174842 | 0.83 | LONP1 (0.39) | PSMB5CLPP | |
| SCHEMBL12754523 | 0.82 | PSMB5 (0.43) | NPY4RNPY1RNPY2RNPY5RPSMB5 | |
| SCHEMBL12754548 | 0.82 | CLPP (0.38) | PSMB5CLPP | |
| SCHEMBL12754443 | 0.81 | LONP1 (0.36) | PSMB5CLPP | |
| SCHEMBL3171354 | 0.81 | PSMB5 (0.49) | PSMB5CLPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233115-B2 | Proteasome inhibitors and methods of using the same | MILLENNIUM PHARMACEUTICALS INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20140088042-A1 | Proteasome Inhibitors And Methods Of Using The Same | CEPHALON, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-8546608-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120041196-A1 | Proteasome Inhibitors and Methods of Using the Same | CEPHALON, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-8058262-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | CEPHALON, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-7915236-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-7576206-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2009-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | PSMB11, PSMB5, PSMB6 | DPP7 1446/4885DPP9 1798/4885DPP8 1581/4885 |
| US-20120041196-A1 | Proteasome Inhibitors and Methods of Using the Same | PSMB11, PSMB5, PSMB6 | DPP7 1446/4885DPP9 1798/4885DPP8 1581/4885 |
| US-20140088042-A1 | Proteasome Inhibitors And Methods Of Using The Same | PSMB11, PSMB5, PSMB6 | DPP7 1446/4885DPP9 1798/4885DPP8 1581/4885 |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | PSMB11, PSMB5, PSMB6 | DPP7 1446/4885DPP9 1798/4885DPP8 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.