Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.38 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209852 | 0.92 | HSD11B1 (0.37) | HRH3SLC6A4HSD11B1BDKRB1SLC6A7 | |
| SCHEMBL208203 | 0.91 | EPHX2 (0.40) | HRH3SLC6A4HSD11B1SLC6A7 | |
| SCHEMBL208314 | 0.89 | HSD11B1 (0.38) | HRH3SLC6A4HSD11B1BDKRB1SLC6A7 | |
| SCHEMBL2758204 | 0.88 | PLA2G2A (0.39) | PLA2G2AHRH3HSD11B1BDKRB1CA12 | |
| SCHEMBL208290 | 0.88 | HSD11B1 (0.38) | HRH3SLC6A4HSD11B1SLC6A7 | |
| SCHEMBL207750 | 0.87 | EPHX2 (0.43) | HRH3SLC6A4HSD11B1SLC6A7PIK3CA | |
| SCHEMBL209250 | 0.86 | EPHX2 (0.40) | HRH3HRH2HRH1SLC6A4HSD11B1 | |
| SCHEMBL14391256 | 0.86 | HSD11B1 (0.39) | HRH3SLC6A4HSD11B1SLC6A7 | |
| SCHEMBL209411 | 0.86 | HSD11B1 (0.39) | HRH3SLC6A4HSD11B1SLC6A7 | |
| SCHEMBL209360 | 0.85 | HSD11B1 (0.38) | HRH3SLC6A4HSD11B1SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090156571-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156571-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD17B1, HSD11B2 | PLA2G2A 3630/4885HRH3 1964/4885HRH2 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.