Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979574 | 0.89 | IMPDH2 (0.48) | — | |
| SCHEMBL10254742 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL10193370 | 0.74 | MAPT (0.46) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL10095308 | 0.73 | IMPDH2 (0.49) | SMN1; SMN2ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL21059104 | 0.72 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL10095328 | 0.69 | IMPDH2 (0.47) | SMN1; SMN2ALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL21059190 | 0.66 | RAB9A (0.73) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL13152103 | 0.66 | MAPK8 (0.44) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL10097783 | 0.65 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 | |
| SCHEMBL13152778 | 0.64 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPK1HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009142-A1 | METHODS FOR TREATING HEPATITIS C | OAT, HAVCR2, HCCS | SMN1; SMN2 4525/4885ALDH1A1 591/4885MAPK1 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.