Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10156631 | 0.92 | ALDH1A1 (0.46) | ALDH1A1MCHR1CYP2D6HRH3HRH4 | |
| SCHEMBL28778123 | 0.92 | MCHR1 (0.47) | ALDH1A1MCHR1CYP2D6HRH3HRH4 | |
| SCHEMBL10156614 | 0.92 | MCHR1 (0.47) | ALDH1A1MCHR1CYP2D6HRH3HRH4 | |
| SCHEMBL28206408 | 0.89 | CA1 (0.46) | ALDH1A1MCHR1HTTEPHX2EPHX1 | |
| SCHEMBL10156619 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MCHR1TP53CYP2D6HRH3 | |
| Trifluoroacetic Acid SCHEMBL28024964 | 0.81 | MCHR1 (0.49) | ALDH1A1MCHR1CYP2D6HRH3HRH4 | |
| SCHEMBL14730628 | 0.80 | LMNA (0.49) | ALDH1A1MCHR1TP53TSHRHTT | |
| SCHEMBL15703919 | 0.79 | HRH4 (0.42) | ALDH1A1MCHR1HRH4EPHX2EPHX1 | |
| SCHEMBL18284105 | 0.79 | HRH4 (0.42) | ALDH1A1MCHR1HRH4EPHX2EPHX1 | |
| SCHEMBL961566 | 0.79 | EPHX2 (0.50) | HRH4EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193164-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-06-05 | — | — | US | disclosed |
| US-20100190784-A1 | Organic Compounds | NOVARTIS AG | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190784-A1 | Organic Compounds | CYP1B1, POLR2A, CYP1A1 | ALDH1A1 193/4885MCHR1 1979/4885TP53 778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.