Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195090 | 0.81 | RIPK1 (0.46) | RIPK1CYP2D6CYP3A4CYP2C19AOC3 | |
| SCHEMBL10229449 | 0.81 | CYP2D6 (0.37) | RIPK1CYP2D6CYP3A4TAAR1CYP2C19 | |
| SCHEMBL235642 | 0.80 | RIPK1 (0.48) | RIPK1CYP2D6CYP3A4TAAR1CYP2C19 | |
| SCHEMBL13435156 | 0.76 | CYP2D6 (0.38) | CYP2D6CYP3A4TAAR1CYP2C19ALDH1A1 | |
| SCHEMBL1019329 | 0.76 | RIPK1 (0.52) | RIPK1TAAR1AOC3ALDH1A1ALOX15 | |
| SCHEMBL24302110 | 0.74 | CYP2D6 (0.43) | CYP2D6CYP3A4TAAR1CYP2C19MEN1 | |
| SCHEMBL1492823 | 0.74 | CYP2D6 (0.43) | CYP2D6CYP3A4TAAR1CYP2C19MEN1 | |
| SCHEMBL28133086 | 0.74 | RIPK1 (0.53) | RIPK1TAAR1AOC3KDM4EALDH1A1 | |
| SCHEMBL14177560 | 0.73 | CYP3A4 (0.49) | RIPK1CYP2D6CYP3A4CYP2C19MEN1 | |
| SCHEMBL5664123 | 0.73 | RIPK1 (0.63) | RIPK1TAAR1AOC3TRPA1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022249-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022249-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | RIPK1 3236/4885CYP2D6 310/4885CYP3A4 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.