Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.72 |
| ▸ | SYK | P43405 | 2/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.72 |
| ▸ | FES | P07332 | 1/20 | 0.72 |
| ▸ | FER | P16591 | 1/20 | 0.72 |
| ▸ | FRK | P42685 | 1/20 | 0.72 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.72 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.72 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426310 | 1.00 | TYK2 (0.72) | TYK2SYKIRAK4FESFER | |
| SCHEMBL426311 | 1.00 | TYK2 (0.72) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL426300 | 0.84 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL29387519 | 0.84 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL426299 | 0.84 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL29365634 | 0.84 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL29459498 | 0.84 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| SCHEMBL18115402 | 0.82 | TYK2 (0.78) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL3082380 | 0.81 | PIKFYVE (0.91) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL29387226 | 0.81 | PIKFYVE (0.91) | TYK2SYKIRAK4FESFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180271873-A1 | METHODS FOR TREATING VIRAL INFECTIONS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH | 2018-09-27 | — | — | US | disclosed |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| WO-2016168420-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| WO-2016161176-A1 | METHODS FOR TREATING VIRAL INFECTIONS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016161176-A1 | METHODS FOR TREATING VIRAL INFECTIONS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-10-06 | — | — | WO | disclosed |
| US-20150174132-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP (US) | 2015-06-25 | — | — | US | disclosed |
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |
| US-20110288081-A1 | PYRIMIDINE COMPOUNDS AND USES THEREOF | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110098267-A1 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-04-28 | — | — | US | disclosed |
| US-20100120722-A1 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | SYNTA PHARMACEUTICALS CORP. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120722-A1 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | SYNTA PHARMACEUTICALS CORP. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20090163708-A1 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163708-A1 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-06-25 | — | — | US | disclosed |
| US-7465725-B2 | Pyrimidine compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465725-B2 | Pyrimidine compounds | SYNTA PHARMACEUTICALS CORP. (US) | 2008-12-16 | — | — | US | disclosed |
| US-20080058297-A1 | Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058297-A1 | Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070032493-A1 | Method for treating B cell regulated autoimmune disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-08 | — | — | US | disclosed |
| US-20070032493-A1 | Method for treating B cell regulated autoimmune disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098267-A1 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | IL17A, IL23R, IL15 | TYK2 826/4885SYK 1106/4885IRAK4 381/4885 |
| US-20150174132-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | REL, NFATC1, BCL6 | TYK2 2464/4885SYK 737/4885IRAK4 660/4885 |
| US-20080058297-A1 | Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss | BRCA1, VHL, ESR1 | TYK2 2409/4885SYK 3624/4885IRAK4 2390/4885 |
| US-20180271873-A1 | METHODS FOR TREATING VIRAL INFECTIONS | HAVCR2, CCL11, EIF2AK2 | TYK2 3663/4885SYK 2919/4885IRAK4 736/4885 |
| US-20100120722-A1 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | BRCA1, VHL, ESR1 | TYK2 2409/4885SYK 3624/4885IRAK4 2390/4885 |
| US-20110288081-A1 | PYRIMIDINE COMPOUNDS AND USES THEREOF | RORC, IL23R, ORC3 | TYK2 70/4885SYK 123/4885IRAK4 291/4885 |
| US-20090163708-A1 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | IL17A, IL23R, IL2 | TYK2 1275/4885SYK 550/4885IRAK4 120/4885 |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | GAA, GBA1, MAN2B1 | TYK2 4587/4885SYK 3861/4885IRAK4 4107/4885 |
| US-20070032493-A1 | Method for treating B cell regulated autoimmune disorders | REL, NFATC1, BCL6 | TYK2 2464/4885SYK 737/4885IRAK4 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.