Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.64 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.43 |
| ▸ | SMO | Q99835 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL704993 | 0.94 | ALOX5AP (0.61) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL2248223 | 0.90 | ALOX5AP (0.55) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL480305 | 0.84 | ALOX5AP (0.69) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL708920 | 0.84 | ALOX5AP (0.59) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL480396 | 0.84 | ALOX5AP (0.77) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL14275821 | 0.82 | ALOX5AP (0.66) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL13262236 | 0.82 | ALOX5AP (0.66) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL15136278 | 0.82 | ALOX5AP (0.47) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL708520 | 0.82 | ALOX5AP (0.58) | ALOX5APPARP10ADAMTS4HDAC3HDAC4 | |
| SCHEMBL2999279 | 0.81 | PARP10 (0.57) | ALOX5APPARP10MAPK14SMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 14/4885PARP10 988/4885ADAMTS4 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.