Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.66 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.66 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10198031 | 0.90 | DGAT1 (0.82) | DGAT1SOAT1SOAT2PREP | |
| SCHEMBL409195 | 0.90 | DGAT1 (0.82) | DGAT1SOAT1SOAT2PREP | |
| SCHEMBL409194 | 0.90 | DGAT1 (0.82) | DGAT1SOAT1SOAT2PREP | |
| SCHEMBL10197337 | 0.89 | DGAT1 (0.83) | DGAT1SOAT1SOAT2KDRPREP | |
| SCHEMBL13190284 | 0.88 | DGAT1 (0.61) | DGAT1SOAT1SOAT2CYP3A4KDR | |
| SCHEMBL10197379 | 0.86 | DGAT1 (0.65) | DGAT1SOAT1SOAT2PREPCNR1 | |
| SCHEMBL10197400 | 0.84 | DGAT1 (0.62) | DGAT1SOAT1SOAT2PREPCNR1 | |
| SCHEMBL10197360 | 0.84 | DGAT1 (0.62) | DGAT1SOAT1SOAT2PREPCNR1 | |
| SCHEMBL10197380 | 0.81 | DGAT1 (0.59) | DGAT1SOAT1SOAT2KDRPREP | |
| SCHEMBL10197402 | 0.81 | DGAT1 (0.58) | DGAT1SOAT1SOAT2KDRPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | DGAT1 2/4885SOAT1 18/4885SOAT2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.